We evaluated 750 patients who retrospectively presented with STEMI and underwent PPCI within 12 h of symptom onset between January 2012 and January 2014. Material and methods Study design and patients In this study, we investigated the association between TIMI risk score and NLR, PLR and other biochemical indices in patients with STEMI undergoing PPCI. The relationship between NLR, PLR and TIMI risk score in patients with STEMI has never been studied. Recently, the platelet to lymphocyte ratio (PLR) has been proposed to be a pro-thrombotic and inflammatory marker. The association between low lymphocyte count and major adverse cardiovascular outcomes (MACE) has also been shown in several studies. However, platelets have a major effect on the formation of atherothrombosis, and therefore play an important role in the pathogenesis of acute coronary syndrome (ACS). Platelets are a source of inflammatory mediators. Several studies have shown that the neutrophil to lymphocyte ratio (NLR) is a prognostic marker in patients with CAD. The thrombolysis in myocardial infarction (TIMI) risk score for STEMI was calculated as the sum of independent predictors of mortality and ischemic events and derived from STEMI patients in the In TIME II randomized controlled trial. The risk scores applied to patients who are treated exclusively with PPCI have shown favorable results. Thus, risk stratification prior to intervention has great clinical importance to identify patients at higher risk and to optimize their therapeutic management. However, it has been observed that the benefit of PPCI is different in each group of patients and the benefit is greatest in those at high risk. The superiority of primary percutaneous coronary intervention (PPCI) over fibrinolysis has been demonstrated in several studies. Reperfusion therapy, either pharmacological or mechanical, is indicated in patients with STEMI with duration of less than 12 h. This process also affects the development of thrombus that is superimposed on the erosion of an atherosclerotic plaque and consequently causes MI. The inflammatory process that underlines atherosclerosis has a critical role in plaque destabilization. Multiple pathophysiological factors influence this atherosclerotic process, and one of the most important factors is inflammation. Coronary atherosclerosis is the main cause of ST elevation acute myocardial infarction (STEMI). Atherosclerosis is the major cause of cardiovascular disease (CVD). Coronary artery disease (CAD) and acute myocardial infarction (MI) are a major cause of death and morbidity worldwide.
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